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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,328 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

see more...

Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10328)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Meg B.
121 reviews
Beauty Junkie Expert Level 2
His acne treatment is hands down the absolute best for my blemishes. If I apply it in the morning and at night, by the next day my pimple is almost gone. Cannot reccomend this product enough!!!
Lauren K.
Easthampton, MA
18 reviews
Beauty Junkie Expert Level 3
I use this on problem spots, as the product intends. I dont usually see a noticeable difference in a day or two but if I apply it consistently for multiple days, i will see a marked difference. Ive applied it to broken out skin, not just an individual spot, to see if the skin would clear up but it dries the skin out a lot, so probably better to apply to just individual spots. 
Melissa L.
United states
18 reviews
This product is amazing. It literally takes the acne away overnight. You can tell it's doing its magic with the fresh tingling when applying! I would recommend this product over and over again.
Sarah B.
Fort Worth
5 reviews
Absolutely LOVE this product. Does what it claims to do, without irritating my sensitive skin or drying out my skin. I use it every time I have a breakout and have been using it for around 3 years now. I will definitely continue to buy product and others from the brand.
Kristie C.
Johnson City
22 reviews
I was pleased with the outcome of this product. My breakouts were gone within 24-48 hours! This product was bought at walgreens and i feel like it did have the potential of being expensive but it works so it was worth it. The packaging was very eye catching and realizing it was an acne treatment made it easier to buy.
jocelyn r.
89 reviews
Beauty Junkie Expert Level 2
i've repurchased this product plenty of times! it does the job and calms your pimples and gets rid of them. i love this product! you can find it at your local drug store and the price isn't bad! i totally recommend :)
Sarah W.
39 reviews
This product did not respond well with my skin; however, I trust the brand enough to think that it probably works well on others. It is affordable enough to purchase and try out for yourself.
Sam S.
San Diego
12 reviews
This little tiny tube of product actually kicks butt! However, unless I'm getting it in an acne treatment kit, I don't buy it on it's own. It still does the job effectively and cheaply as compared to other brands, so don't be afraid to try it out if you're on a budget.
Meghan S.
28 reviews
Beauty Junkie Expert Level 1
Personally every time I use this product to eliminate a pimple, I don’t feel it really does anything for me. It sort of reduces redness, but not as much as I would hope an acne product would.
Jada M.
Larose, LA
80 reviews
Beauty Junkie Expert Level 2
You guys made me buy it lol!! " claims to not over dry but I'll see lol 100% of people showed clearer skin in just one day" also it is very small for the price so I let you guys know if this is a hit or flonk!
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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