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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,303 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10303)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Brooke G.
Westerville, OH
102 reviews
Beauty Junkie Expert Level 2
One thing I love about this product is that within an hour of juice, it has helped to take the redness down! Typically, I will put the spot treatment on and sleep with it, and by morning, any sort of blemish is nearly nonexistent! This is my first round of use with this product, and I will be re-purchasing!
Madison P.
95 reviews
Beauty Junkie Expert Level 1
I love this product for quick treatment of single pimples or blemishes. It’s super gentle and very effective! Works really well on any size of pimple and it makes for an easy acne treatment! I would definitely repurchase
Jordan h.
50 reviews
Beauty Junkie Expert Level 1
This works and helped my little pimples that didn’t want to leave soooooooooooooooooooooooo for sure get this product it works so well and yea just try it out you can buy it at Walmart target Walgreens umm any drugstore
Amanda V.
Valley Falls, KS
361 reviews
Beauty Junkie Expert Level 5
I love this product. I use it every night for those stubborn pimples that always pop up. Even after turning 30 I still have horrible acne and this seems to help tame those horrible pimples. Definitely will always buy!!!!
Ashley C.
Dahlonega, GA
38 reviews
Beauty Junkie Expert Level 1
My go to. This stuff never lets me down! If I need a spot gone over night then this is what I use. The great thing is you can apply up to three times a day (depending on skin dryness) and it even fades left behind marks and redness! Such a great spot treatment but especially for such an affordable price point.
Jensen R.
32 reviews
Beauty Junkie Expert Level 1
I liked this product. It like the color of the packaging. I also like the size of the product and the price makes it easy to travel. I also like how effective it was. It definitely cleared up acne in spots like it says.
Jill C.
Lawrenceburg, KY
53 reviews
Beauty Junkie Expert Level 1
This product is great. Even my husband uses it. If there is a spot coming up on my face, I apply a small amount at bedtime and the next morning I can tell a difference in the area. It last a long time
And works wonders.
Francesca B.
Robertsdale, AL
150 reviews
Beauty Junkie Expert Level 4
This does what it is supposed to do. It dries up pimples. I do think this is a very strong formula for drug stores, so I would recommend this over other brands. It can dry out your skin very easily. I found that when I used this regularly in the past, I would have terrible dry patches. But I would buy again.
Amy J.
Salt Lake Cty, UT
225 reviews
Beauty Junkie Expert Level 3
For me, this is not a good product for small pimples, because I find they go away faster if I continue with my daily routine and drink water and eat healthy. But for the big pimples that come out of nowhere? This is the ticket, and pretty much the only thing that works for getting those things to go away.
Kaï N.
Farmers Brnch, TX
13 reviews
I had a major pms pimple on my chin and used this product and my expectations were unrealistic I thought it was gonna go away that same day so I kept apply and I woke up the next morning and it had dried out tremendously and the following day went away completely . I would definitely recommend this product
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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