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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,274 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

see more...

Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10274)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Chelsea C.
Churchville, NY
187 reviews
Beauty Junkie Expert Level 2
Works well, but the Neutrogena spot clear works a lot better for the same ingredient. I use this when I need to clear spots under makeup, or during the day. At night I swear by the drying lotion from Mario Badescu. This is quick, dries clear, and helps keep pimples from spreading and getting worse. Just doesn’t work as well/as quickly as the Neutrogena like I mentioned.
Bianca M.
Roslyn Hts, NY
186 reviews
Beauty Junkie Expert Level 3
I'm generally a fan of Clean & Clear products so naturally I had to try this.  I can't say it cleared pimples overnight but gradually did help dry them out, as would anything over a period of time though.  I personally prefer benzoyl peroxide than salicylic acid.
Yesenia R.
24 reviews
This was one of the first few acne spot treatments I used, and I did not like it very much. It left my skin really dry and it would give me a burning sensation. It did help me get rid of some acne, but I would not buy this again. It stopped working after a while.
Rhiannon S.
La Belle
87 reviews
Beauty Junkie Expert Level 1
I honestly do not recommend this to anyone. Maybe it's just me but I did not like it. It dried so quickly and made the area where I put it patchy and itchy. It also burned just a little so I tossed it out and won't buy it again. It's unfortunate because it's a first for me from this brand.
Purnima D.
278 reviews
Beauty Junkie Expert Level 2
This works over night and I wouldn’t have to touch my pimple again and it does not leave any acne marks when I used it. It has nice packaging and really made my pimple go away over night! Never seen a pimple leave before it formed until using this product.
Melissa V.
Houston, TX
231 reviews
Awww... I hate giving a bad review, but this was very not very thick, even for a gel. I shook it up, but after 3 days of usage, I was not pleased. I suppose if you don't have a lot of whiteheads/acne this could do the trick, not for cystic acne (obviously). I would actually prefer a thicker cream. It is very affordable however and available like, everywhere. 
Monet W.
Southfield, MI
188 reviews
Beauty Junkie Expert Level 3
I like this product but i dont love it. it doesn't work as immediately as you would think. But i does the job of drying out the pimple. But it stings a little which actually doesn't bother me. I dont have super sensitive skin so i can withstand it
Anna N.
Morgan, UT
10 reviews
This stuff works pretty well! It's got a great price too. It wasn't as amazing as I'd hoped, it's a hit or miss kind of product. It's small and handy for on the go. I would maybe buy it again, it's a useful spot treatment.
Hazel A.
47 reviews
Beauty Junkie Expert Level 1
At first when I picked up this product I thought it was going to help me tackle my acne but unfortunately that was not the case. Maybe it is just me but instead of fighting my acne it gave me new breakouts all over the area that I applied it on.
Hannah S.
Simi Valley, CA
49 reviews
Beauty Junkie Expert Level 1
This product is fantastic for the few pesky giant zits that you have. This product weakens the acne and shrinks it in the span of one night. Definitely effective. It does kind of smell like beer so if you don’t like that smell then don’t buy it.
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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