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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,332 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10332)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Carisa P.
Arlington, TX
69 reviews
Beauty Junkie Expert Level 2
This little tube of dynamite stays on any travel bag/purse that I carry as well as additional tubes in both mine and my husbands bathrooms. I found this great steal about 5 years ago at a local Walgreens and have used it to overnight treat acne as well as (it is not for this technically) cold sores that have yet to form completely. It must be the amount of salicylic acid in the formula. I will continue to use this as long as it is produced.
Estefany N.
johnson city
250 reviews
Beauty Junkie Expert Level 4
I suffered from acne in high school so I bought a clean and clear acne kit which this came in. I would use the cleanser and moisturizer at night then if I had any spots apply this on. By morning, this would have reduced redness so much! I liked to pop my zits then put this and even retouch in the morning. I think this prevented me from scarring too. My skin has been controlled now and I do not get acne anymore but I always remember how much this came in handy for spot acne!
Beth M.
4 reviews
I have tried this product several times and it doesn’t ever seem to work for me, I know others who have used it and swear by it but all it does to me is burn my face and just make the area I applied even more red and irritated .. I will not be purchasing this particular product again . But love the clean and clear brand itself 
Jenny M.
80 reviews
Beauty Junkie Expert Level 2
I notice a clear difference in the size of my pimples/their level of redness when i use it. But i suggest the persa-gel over this for people with harsher problem areas because this one won’t do the job for big acne patches. It does help smaller pimples and reduces swelling a lot in areas that i have blackheads or sebum. I recommend
Sarah T.
San Jose, CA
40 reviews
Beauty Junkie Expert Level 1
Usually I apply ointments for my pimples before I go to bed. When I used this ointment thought, the next day I don't see any improvement to my face. The pimples didn't grow bigger but it didn't seem like it shrunk in size at all. Usually when I could feel some sort of tingle or sensation happening on my face when a skin care product is on my face for a few minutes, but I didn't feel anything happening at all with this ointment. Doesn't work with my skin type.
Briana E.
Louisville , KY
114 reviews
Beauty Junkie Expert Level 2
I am all about a good spot treatment. I get bad cystic acne so anything I can do to stop a breakout in its tracts is what I’m looking for.

Contains 2% Salicylic acid which makes it so great for breakouts as well as witch hazel - which also soothes the skin. I also love that it doesn’t OVER DRY the skin.

Purchased for $6 at target.
Massiel R.
New york, NY
51 reviews
Beauty Junkie Expert Level 1
This little guy is so small yet so powerful. I've been using this for years now when I get those random pesky breakouts. After my face wash routine I will throw this on any breakout I may have and within ours it dries it up and reduced redness. Definitely very travel friendly, comes in a small tube which you can just throw in your purse and have it on the go.
Hannah Z.
Raleigh, NC
15 reviews
Beauty Junkie Expert Level 1
This stuff is magic!! I've been using it for years and don't plan on stopping any time soon! I've got sensitive skin and this is one of the few products I've found that gets the job done without irritating my face. Whenever a blemish comes up I simply put a small amount of this product right on the blemish after going through my nightly skincare regime. The tube is small but if you're using it right it lasts a while! One trick I suggest it DON'T rub it in!
Nicole G.
33 reviews
Beauty Junkie Expert Level 1
THE BEST & MY GO-TO. Seriously, this stuff really works. Amazing treatment for a very affordable price. It even cleans blackheads as well as prevents breakouts. I apply it several times a day (and keep breakouts clean!) and my breakouts are completely gone in about 2 days. The package is small, but it lasts many applications!
Tali O.
39 reviews
Beauty Junkie Expert Level 1
This helps treats acne spots that are emerging very shallow. If it is a deep acne spot coming on this will not help prevent or kill it. The pimple will have to emerge first and have a thin layer of skin over it. If it’s thick, then you have to prick it first then get it in to get this to work. Haven’t found anything better yet.
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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