I have been taking these for about a year now. Took them before being pregnant, while pregnant, and now breastfeeding and still continuing. They are fantastic. They have never made me sick at any time and I always take them before bed, meaning mostly empty stomach. They were created so you didn't need to take them with food, and you don't. Exactly what I needed in a prenatal because there was no way I would remember to take them if I had to at a meal. The pill is large though, it may be hard for some people to take down!